"Police respond to active shooter at Colorado supermarket, AstraZeneca says U.S. trial shows its Covid vaccine is 79 percent effective, and Miami Beach extends state of emergency amid spring break crowds. Watch “NBC Nightly News With Lester Holt” at 6:30 p.m. ET / 5:30 p.m. CT (or check your local listings).00:00 Intro02:03 Multiple Fatalities In Colorado Supermarket Shooting03:38 AstraZeneca: Vaccine 79 Percent Effective In U.S. Trial06:13 Miami Beach Extends Spring Break State Of Emergency07:21 CDC Warns Of 'Avoidable Surge' As Restrictions Lifted08:06 First Images Inside Texas Child Migrant Detention Center09:01 Over 15,000 Migrant Children Detained In U.S. Custody09:45 ICE Cuts $87 Million Deal To House Migrants In Hotels10:17 Protests Nationwide In Wake Of Spa Shooting Rampage10:48 Officials: Not Enough Evidence Of Hate Crime As Of Now11:36 Growing Outrage Among Asian Americans After Rampage11:50 NYPD Searching For Suspect Who Attacked Protester12:19 Volunteers Escort The Elderly As Anti-Asian Attacks Rise13:16 Gas Prices Soar To Nearly Two-Year High14:42 Getting Help Paying For Skyrocketing College Costs16:44 New Orleans Black Community Reeling From Covid » Subscribe to NBC News: http://nbcnews.to/SubscribeToNBC» Watch more NBC video: http://bit.ly/MoreNBCNewsConnect with NBC Nightly News online! NBC News App: https://smart.link/5d0cd9df61b80Breaking News Alerts: https://link.nbcnews.com/join/5cj/breaking-news-signup?cid=sm_npd_nn_yt_bn-clip_190621Visit NBCNightlyNews.com: https://nbcnews.to/2wFotQ8Find Nightly News on Facebook: https://bit.ly/2TZ1PhFFollow Nightly News on Twitter: https://bit.ly/1yFY2s4Follow Nightly News on Instagram: https://bit.ly/2tEncJD NBC News Digital is a collection of innovative and powerful news brands that deliver compelling, diverse and engaging news stories. NBC News Digital features NBCNews.com, MSNBC.com, TODAY.com, Nightly News, Meet the Press, Dateline, and the existing apps and digital extensions of these respective properties. We deliver the best in breaking news, live video coverage, original journalism and segments from your favorite NBC News Shows.#ColoradoSupermarket #CovidVaccine #NBCNewsNBC Nightly News Broadcast (Full) - March 22nd, 2021 | NBC Nightly News"